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Publications

2019

6. A. Sau, C. Palo-Nieto, M. C. Galan*

73. C. Palo-Nieto,§ A. Sau,§  R. Jeanneret,  P.-A. Payard,  M. Braga Martins-Teixeira, I. Carvalho  and L. Grimaud M. C. Galan*"Copper Reactivity Can be Tuned to Catalyse the Stereoselective Synthesis of 2-Deoxy Glycosides from Glycals". (2019) ChemRxiv. doi.org/10.26434/chemrxiv.9272684.v1

72. S.A. Hill,§ S. Sheikh,§ Q. Zhang, L. Sueiro Ballesteros, A. Herman, S. A. Davies, D. J. Morgan, M. Berry, D. Benito-Alifonso, M. C. Galan*"Selective Photothermal Killing of Cancer Cells Using LED-Activated Nucleus Targeting Fluorescent Carbon Dots".  (2019), 1, 2840-2846. DOI:10.1039/C9NA00293F

71. S. Michel, F. Dutertre, M. Denbow, M. C. Galan* and W. Briscoe "Facile Synthesis of Chitosan-Based Hydrogels and Microgels through Thiol-Ene Photoclick Crosslinking" ACS Appl. Biomat. (2019) Accepted. DOI:10.1021/acsabm.9b00218

70. M. O'Hagan*, J. C. Morales, M. C. Galan* "Binding and beyond: what else can G-quadruplex ligands do?" Eur. J. Org. Chem. (2019) Accepted DOI:10.1002/ejoc.201900692 and Cover Feature

69. K. Huang, F. Parmeggiani, H. Ledru, K. Hollingsworth, J. Mas Pons, A. Marchesi, P. Both, A. P. Mattey, E. Pallister, G. S. Bulmer,  J. M. van Munster,  W. B. Turnbull, M. C. Galan,* S. L. Flitsch* "Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases" Org. Biomol. Chem. (2019) Accepted. DOI:10.1039/C9OB01089K

part of the themed collection: Chemical biology in OBC

68. M. Duchi, M.P. O’Hagan, R. Kumar, S.J. Bennie, M.C. Galan, B.F.E. Curchod and T.A.A. Oliver* "Exploring ultraviolet photoinduced charge-transfer dynamics in a model dinucleotide of guanine and thymine." Phys. Chem. Chem. Phys. (2019), 21, 14407. Photodissociation and reaction dynamics special issue. DOI: 10.1039/C8CP07864E

67. M.P. O’Hagan, S. Haldar, M. Duchi, T.A.A. Oliver, A. J. Mulholland, J.C. Morales and M.C. Galan*. "A photoresponsive stiff-stilbene ligand fuels the reversible unfolding of G-quadruplex DNA". Angew. Chem. Int. Ed. (2019), 131, 1. DOI:10.1002/anie.201900740

 

66. A. Sau, C. Palo-Nieto, M. C. Galan* “Substrate-controlled direct stereoselective synthesis of deoxyglycosides from glycals” J. Org. Chem. (2019), 84, 2415. DOI: 10.1021/acs.joc.8b02613 

2018

65.  I. Sittel, M.C. Galan* "Application Of Ionic Liquid And Fluorous Tags In Oligosaccharide Synthesis". Book Chapter in "Protecting Groups - Strategies and Applications in Carbohydrate Chemistry" S. Vidal editor, Wiley-VCH publishers. Release date: Dec. 2018. ISBN: 978-3-527-34010-1

64. T.A. Swift, T.A.A. Oliver, M.C. Galan, H.M. Whitney. "Functional nanomaterials to augment photosynthesis: evidence for future applications in food security" (2018) Interface Focus 9: 20180048. DOI:10.1098/rsfs.2018.0048

63. C. S. Bennett* and M. C. Galan*. “Methods for 2-Deoxyglycoside Synthesis.” Chem. Rev., 2018, 118, 7931. DOI: 10.1021/acs.chemrev.7b00731

62. D. Benito-Alifonso, B. Richichi, V. Baldoneschi,M. Berry,M. Fragai, G. Salerno, M. C. Galan,* and C. Nativi* “Quantum Dot-based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases (MT-MMPs).” ACS Omega 2018, 3, 9822. DOI: 10.1021/acsomega.8b00633

 

61. S. A. Hill, D. Benito-Alifonso, S. A. Davis, D. J. Morgan, M. Berry, and M. C. Galan* “Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure” Scientific Reports, 2018, 8,12234. DOI:10.1038/s41598-018-29674-2 

60. T. A. Swift, M. Duchi, S. A. Hill, D. Benito-Alifonso, R. L. Harniman, S. Sheikhac, S. A. Davis, A. M. Seddon, H. M. Whitney, M. C. Galan* and T. A. A. Oliver*.“Surface nanoparticle functionalization affects the physical and electronic structure of fluorescent carbon dots.” Nanoscale, 2018, 10, 13908.

DOI: 10.1039/C8NR03430C Nanoscale top 5% most-read Q3

2017

59. C. Palo-Nieto, A. Sau and M. C. Galan* "Gold(I)-Catalysed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals" J. Am. Chem. Soc.  2017, 139, 14041. Featured in Synfacts 

58. R. Williamns and M. C. Galan*. "Recent Advances in Organocatalytic Glycosylations" Eur. J. Org. Chem.  2017, 6247. EurJOC Readers‘ Choice 2019 

 

57. A. Sau and M. C. Galan*. "Palladium-Catalyzed α-Stereoselective O-Glycosylation of O(3)-Acylated Glycals" Org. Lett. 2017, 19, 2857.  

 

56. K. Röttger, H.J.B. Marroux, A. F. M. Chemin, E. Elsdon, T. A. A. Oliver, S. T. G. Street, A. S. Henderson, M. C. Galan, A. J. Orr-Ewing*, and G. M.Roberts*. "Is UV-induced. Electron-Driven Proton Transfer Active in a Chemically Modified A.T DNA Base Pair?"     J. Phys.Chem. B. 2017, 121 (17), 4448. 

 

55. I. Sittel and M. C. Galan*. "Imidazolium-labeled Glycosides as Probes to Harness Glycosyltransferase Activity in Human Breast Milk".  Org. Biomol. Chem. 2017, 15, 3575. Published in themed collection 2017 Hot Articles in Organic and Biomolecular Chemistry. Also featured in OBC Blog - https://rsc.li/2qbTWdA 

54. S. A. Hill and M. C. Galan*. "Fluorescent Carbon Dots from Mono- and Polysaccharides: Synthesis, Properties and Applications". Beilstein J. Org. Chem. 2017, 13, 675.  

53. S. T. G. Street, D. N. Chin, G. J. Hollingworth, M. Berry, J. C. Morales* and M. C. Galan*. "Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K+ Buffer". Chem. Eur. J. 2017, 23, 6953.

 

52. B. T. Miles, A. B. Greenwood, D. Benito-Alifonso, H. Tanner, M. C. Galan, P. Verkade and H. Gersen*. "Direct Evidence of Lack of Colocalisation of Fluorescently Labelled Gold Labels Used in Correlative Light Electron Microscopy" Scientific Reports. 2017, 7, 44666.

 

51.  A. Sau, R. Williams, C. Palo-Nieto, A. Franconetti, S. Medina and M. C. Galan* "Palladium-Catalysed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals" Angew. Chem. Int. Ed. 2017, 56, 640. 

 

50. C. Palo-Nieto, A. Sau, R. Williams and M. C. Galan* “Cooperative Brønsted Acid-Type Organocatalysis for the Stereoselective Synthesis of Deoxyglycosides."  J. Org. Chem. 2017, 82, 407. 

49. D. Benito-Alifonso, M.C. Galan* "Bronsted and Lewis Acid Catalyzed Glycosylation". Book Chapter in "Selective Glycosylations - Synthetic Methods and Catalysts" C. Bennet  editor, Wiley-VCH publishers. 2017, ISBN: 978-3-527-33987-7. 

2016

48. S. A. Hill, D. Benito-Alifonso, D.J. Morgan, S.A. Davis, M. Berry, M. C. Galan*  "Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery". Nanoscale 2016 , 8, 18630. 

47. S. Medina, M. J. Harper, E. I. Balmond, S. Miranda, G. E. M. Crisenza, D. Coe, E. McGarrigle and M. C. Galan* "Stereoselective Glycosylation of 2-Nitrogalactals Catalysed by a Bifunctional Organocatalyst" Org. Lett. 2016, 18, 4222. 

46. T. S. Carter, T. J. Mooibroek, P. F. N. Stewart, M. P. Crump, M. C. Galan and A. P. Davis. "Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water". Angew. Chem. Int. Ed. 2016, 55, 9311. 

45.  A. S. Henderson, C. Pifferi and M. C. Galan*. "Synthesis of methyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α- and β-D-glucopyranosides". In Carbohydrate Chemistry: Proven Synthetic Methods,” Volume 4, P. V. Murphy Ed., CRC Press, 2016.

44. A. S. Henderson, J. Bower* and M. C. Galan*. "Carbohydrate as Enantioinduction Components in Stereoselective Catalysis". Org. Biomol. Chem. 2016, 14, 4008.

 

43. D. Benito-Alifonso, S. Tremel, J. Sadler, M. Berry* and M. CarmenGalan*. "Imidazolium-Tagged Glycan Probes for Non-covalent Labeling of Live Cells". Chem. Commun. 2016, 52, 4906 - 4909.

 

42. R. Beattie, T. Hornsby, G. Craig, M. Carmen Galan* and C. L. Willis*. "Stereoselective Synthesis of Protected L- and D-Dideoxysugars and Analogues via Prins Cyclisations. Chem. Sci., 2016, 7, 2743-2747.

 

41. S. Medina and M. Carmen Galan*. "Recent developments in the stereoselective synthesis of deoxy glycosides". Carbohydr. Chem. 2016, 41, 59–89.

2015

40. K. Röttger, H. J. B. Marroux M. P. Grubb, P. M. Coulter, H. Böhnke, A. S. Henderson, M. C. Galan, F. Temps*,A. J. Orr-Ewing* and G. M. Roberts*. "Ultraviolet Absorption Induces Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution". Angew. Chem. Int. Ed. 2015, 54, 14719-14722. 

 

39. A. S. Henderson, S. Medina, J. Bower* and M. C. Galan*. "Nucleophilic aromatic substitution (SNAr) as an approach to challenging carbohydrate-aryl ethers" Org. Lett. 2015,17 (19), 4846–4849.

 

38. I. Sittel and M. C. Galan*. "Chemo-enzymatic Synthesis of Imidazolium-Tagged Sialyllactosamine Probes" Bioorg. Med. Chem. Lett. 25, 2015, 4329-433.

37. S. Medina, A. Henderson, J. Bower and M. C. Galan*. "Stereoselective Synthesis of Glycosides using (salen)Co catalysts as promoters" Chem. Commun. 2015, 51, 8939-8941.

2014

36. A. S. Henderson, J. Bower* and M. C. Galan*, "Carbohydrate-Based N-Heterocyclic Carbenes for Enantioselective Catalysis"  Org. Biomol. Chem., 2014, , 12, 9180 – 9183.

 

35. E. I. Balmond, D. Benito-Alifonso, D. M. Coe, R. W. Alder, E. M. McGarrigle,* M. C. Galan* "3,4-Trans-Fused Cyclic Protecting Group Helps Achieve α-Selective Catalytic Synthesis of 2-Deoxyglycosides". Angew. Chem. Int. Ed. 2014, 53, 8190 –8194.

34. B. Hou, D. Benito-Alifonso, R. Webster, D. Cherns, M. C. Galan, D. J. Fermín* "Rapid Phosphine-Free Synthesis of CdSe Quantum Dots:  Promoting the Generation of Se Precursors by a Radical Initiator". J. Mat. Chem. A. 2014, 2, 6879-6886.

 

33. D. Benito-Alifonso, S.Tremel, B. Hou, H. Lockyear, J. Mantell, D. Fermin, Paul Verkade, M. Berry* and M. C. Galan*. "Lactose as a “Trojan Horse” for Quantum Dot Cell Transport".  Angew. Chem. Int. Ed. 2014, 53, 810-814. (Highlighted as a Hot Paper) 

 

32. E. I.  Balmond, E. McGarrigle* and M. C. Galan*. "N,N'-Bis[3,5-bis(trifluoromethyl)phenyl]thiourea"  (2014) e-EROS [Online], John Wiley & Sons Ltd., https://onlinelibrary.wiley.com/book/10.1002/047084289X. 

2013

 

31. B. Hou, D. Benito-Alifonso, Nessrin Kattan, David Cherns, M. Carmen Galan and D. J. Fermín*. "Initial stages in the formation of Cu2ZnSn(S,Se)4 nanoparticles" Chem. Eur. J. (2013), 19, 15847 – 15851

30. D. Benito-Alifonso, R. A. Jones, A.-T.Tran, H. Woodward, N. Smith and M. Carmen Galan*. "Synthesis of mucin-type O-glycan probes as aminopropyl glycosides" Beilstein J. Org. Chem. (2013), 9, 1867–1872.


29. E. I. Balmond, M. C. Galan* and E. McGarrigle* "Recent Developments in the Application of Organocatalysis to Glycosylations" Synlett,  (2013); 24(18): 2335-2339.

 

28. M. C. Galan*, R. A. Jones and A.T. Tran, Recent Development of Ionic Liquids in Oligosaccharide Synthesis. The Sweet side of Ionic Liquids. (2013) Carbohydr. Res. (2013), 375 (2013) 35–46.

27. M. C. Galan, P. Dumy and O. Renaudet*, Multivalent Glyco(cyclo)peptides. Chem. Soc. Rev. (2013), 42, 459.

 

26. I. Sittel, A.T. Tran, D. Benito-Alifonso and M. C. Galan*, Combinatorial IOnic Catch and Release Oligosaccharide Synthesis (Combi-ICROS). Chem. Commun. (2013), 49 (39), 4217-4219.

2012

25. E. I. Balmond, D. M. Coe, M. C. Galan*, E. Mcgarrigle*,Alpha-Selective Organocatalytic Synthesis of 2-Deoxygalactosides. Angew. Chem. Int. Ed. (2012), 51, 36, 9152-9155. Highlighted in Synfacts (2012), 8 (10) 145.

24. M. C. Galan*, A.-T. Tran, K. Bromfield, S. Rabbani and B. Earnst. Chemo-enzymatic Synthesis of Ionic-Liquid Tagged Oligosaccharide Probes. Org. Biomol. Chem. (2012), 10, 7091-7097.


2011

23. M. C. Galan*, A. T. Tran, J. Boisson, D. Benito, C. Butts, J. Eastoe and P. Brown. [RN4] [AOT]: A surfactant ionic liquid as a mild glycosylation promoter. J. Carbohydr. Chem. (2011), 30, 486-497. Special Issue of the European Young Investigators Workshop on Carbohydrate Chemistry.

22. A.T. Tran, Rachel A. Jones, J. Pastor, J. Boisson, N. Smith and M. C. Galan*. Copper (II) triflate: a versatile catalyst for the one-pot preparation of orthogonally protected glycosides. Adv. Synth. Cat. (2011), 353 (14 - 15), 2593 - 2598.

21. A.T. Tran, R. Burden, T.D. Racys and M.C. Galan*. Ionic Catch and Release Oligosacharide Synthesis (ICROS). Chem. Commun. (2011), 47 (15), 4526 - 4528.


20. M. C. Galan*, D. Benito-Alifonso and G. M. Watt. Carbohydrate Chemistry in Drug Discovery. Org. Biomol. Chem. (2011), 9 (10), 3598 - 3610. Amongst the top ten most accessed articles during the month of March and May.

2010

19. M.C. Galan*, A.T. Tran, C. Bernard. Ionic Liquid based Catch and Release MS Tags for Enzyme monitoring.Chem. Commun. (2010) 46 (47), 8968 - 8970 

 

18. M. C. Galan* and Anthony P. Corfield. Ionic liquids in oligosaccharide synthesis: toward mucin type glycan probes. Biochem. Soc. Trans. (2010),38, 1368-1373.

17. R.A. Jones, R.A. Davidson, A.T. Tran, N. Smith and M.C. Galan*. Iodine catalyzed one pot acetalation-esterification reaction for the preparation of orthogonally protected glycosides. Carbohydr. Res. (2010), 345, 1842-1845 


16.   M.C. Galan*, A.T. Tran, S. Whitaker. [bmim][OTf] as co-Solvent/Promoter in Room Temperature Reactivity-Based One Pot Glycosylation Reactions. Chem. Comm. (2010) 46, 2106-2108

15.   M.C. Galan*, K. Jouvin, D. Alvarez-Dorta. Scope and Limitations of Imidazolium Based Ionic Liquids as Room Temperature Glycosylation Promoters. Carbohydr. Res. (2010) 345, 45-49

 

2009

14. M.C. Galan*, C. Brunnet, M. Fuensanta. [Bmim][OTf]: A Versatile Room Temperature Glycosylation Promoter. Tetrahedron Lett. (2009), 50, 442-445.



2000-2008

Publications with PhD and Post-doctoral Supervisors 

13. N. Yerkes, JX Wu, E. McCoy, M.C.Galan, S.Chen, S.E. O'Connor. Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis. Bioorg Med Chem Lett. (2008),18(10), 3095-8.

12. M.C. Galan, E. McCoy, S.E. O'Connor. Chemoselective derivatization of alkaloids in periwinkle. Chem. Comm (2007), 3249 - 3251. Highlighted as a Hot Paper by Chem. Comm.

11. S. Chen1, M.C. Galan1, C. Coltharp, S.E. O'Connor. Redesign of a central enzyme in alkaloid biosynthesis. Chem. Biol. (2006), 13, 1137-1141. 1Equal contribution.

10. E. McCoy, M.C. Galan, S.E. O'Connor. Substrate specificity of strictosidine synthase. Bioorg. Med. Chem. Lett. (2006) 16, 2475-8.

9. M.C. Galan, S.E. O'Connor. Semisynthesis of Secologanin Analogues. Tetrahedron Lett. (2006), 47 (10): 1563-1565. 

8. D Thayer, H.N. Yu, M.C. Galan, and C.H. Wong. A General strategy towards S-linked Glycopeptides. Angew. Chem. Int. Ed. (2005), 44, 29, 4596-4599.

7. M.C. Galan, A.P. Venot, and G.J. Boons. The Design and Synthesis of a Selective Inhibitor of Fucosyltransferase VI. Org. Biomol. Chem. (2004), 2, 1376-1380.

6. M.C. Galan, C.S. Dodson, A.P. Venot, and G.J. Boons. Glycosyltransferase Activity can be Selectively Modulated by Chemical Modifications of Acceptor Substrates. Bioorg. & Med. Chem. Lett. (2004), 14, 2205-2208.

5. M.C. Galan, A.P. Venot, J. Gluska, A. Imberty and Boons, G.J Chemo-Enzymatic Synthesis of Conformationally Constrained Oligosaccharides. Org. Biomol. Chem. (2003), 1, 3891-3899.

4. M.C. Galan, A.P. Venot, and G.J. Boons. Enzymatic Glycosylation of Conformationally Constrained Saccharides. Biochemistry (2003), 42, 8522 -8529.

3. M.C. Galan, A.P. Venot, J. Gluska, A. Imberty and Boons, G.J. alpha-(2,6)-Sialyltransferase Catalyzed Sialylations of Conformationaly constrained  Oligosaccharides. J. Am. Chem. Soc. (2002), 124, 5964-5973.
 
2. D. Lozano-Castello, D. Cazorla-Amoros, A. Linares-Solano, P.J. Hall, D. Gascon and C. Galan. In situ small angle neutron scattering study of CD4 adsorption under pressure in activated carbons. Carbon, (2001), 39, (9), 1343-1354.

1. C. Galan, L.E.A. Berlouis and P.J. Hall. The effects of electrochemical hydrogenation on coal structure: chemical and macromolecular changes; Fuel, (2000), 79, (12), 1431-1438.