OUR RESEARCH

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OLIGOSACCHARIDE SYNTHESIS 

Access to structurally defined oligosaccharide libraries is key for the advancement of glycobiology research and also for carbohydrate-based drug discovery. We aim to develop general and efficient methodologies for the synthesis of oligosaccharide and glyco-conjugates of biological importance by addressing the key hurdles in oligosaccharide synthesis.

FUNCTIONAL NANOMATERIALS

We design and develop glycan-based fluorescent nano probes as a powerful tool to screen for carbohydrate-mediated interactions and exploit those for therapeutic and diagnostic applications in cancer, antimicrobials and plants. 

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DRUG DISCOVERY

The development of selective and potent anticancer therapeutics is one of the biggest challenges in the area of cancer research. G-quadruplexes are four-stranded guanine rich secondary DNA structures, which are over-represented in gene promoter regions including oncogenes and tumor suppressors. We aim to develop ligands able to stabilised selective G-quadruplex structures as novel anti-cancer therapeutics.

 

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