Pseudo-Enantiomeric Carbohydrate-Based N-Heterocyclic Carbenes as Promising Chiral Ligands for Enantiotopic Discrimination

March 18, 2020

Congratulation to Alex Henderson's last publication from his PhD work where we report the practical synthesis of pseudo-enantiomeric carbohydrate-based NHC–Rh complexes bearing C1 or C3 sterically differentiated positions. We show that steric bulk at C1 gives preference for (S)-phenyl-1-ethanol, while bulk at C3 leads to the (R)-enantiomer, leading to enantiotopic Q2 discrimination.

 

 

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